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Magnetic Nanoparticles for Drug Delivery

Magnetic Nanoparticles for Drug Delivery

Magnetic nanoparticles have been developed for localized drug delivery for patients with cancers. These are directed to the tumor, by acting as a carrier of the drug. Once the drug has reached the patient’s bloodstream, a magnetic field is applied to retain the particles in the targeted site of the tumor.Oct 22, 2018

Which nanoparticles are used in drug delivery?

Nanoparticles used in drug delivery system
  • Chitosan. Chitosan exhibits muco-adhesive properties and can be used to act in the tight epithelial junctions. …
  • Alginate. …
  • Xanthan gum. …
  • Cellulose. …
  • Liposomes. …
  • Polymeric micelles. …
  • Dendrimers. …
  • Inorganic nanoparticles.

How does magnetic drug delivery work?

The tetrapod contains four arms which release the sperm cell in situ when they are pushed into a tumor. A magnetic field allows for controllable magnetic guidance as well as release, allowing drug delivery to tumor cells without damaging the healthy tissue.

What are magnets used for drugs?

Magnetic drug targeting is a method by which magnetic drug carriers in the body are manipulated by external magnetic fields to reach the targeted area. Magnetic drug carriers contain magnetic materials that interact with magnetic fields, usually magnetic nanoparticles such as ferric oxide particles.

Which magnetic substance is favorite for potential use in nanomedicine?

Iron oxide nanoparticles such as magnetite (Fe3O4) or its oxidized form maghemite (?-Fe2O3) are by far the most commonly employed nanoparticles for biomedical applications. Highly magnetic materials such as cobalt and nickel are susceptible to oxidation and are toxic; hence, they are of little interest [2628].

Why are magnetic nanoparticles used in MRI?

Super(paramagnetic) nanoparticles when placed in the magnetic field disturb the field causing faster water proton relaxation, thus enabling detection with MRI.

How nanotechnology is used in targeted drug delivery?

In addition to drug delivery, nanocarriers can be used as biosensors in monitoring and diagnosis for the detection of biomarkers or pathogens by linking quantum dots (QDs) and dyes or using magnetic nanocarriers [1]. Targeted drug delivery systems and therapeutics can be advantageous compared to conventional systems.

What are some properties of nanoparticles that make them attractive for drug delivery and pharmaceutical applications?

The reason why these nanoparticles (NPs) are attractive for medical purposes is based on their important and unique features, such as their surface to mass ratio that is much larger than that of other particles, their quantum properties and their ability to adsorb and carry other compounds.

What is magnetic pill technology?

It’s a completely new way to design a drug delivery system. The two main components of the system are conventional-looking gelatin capsules that contain a tiny magnet, and an external magnet that can precisely sense the force between it and the pill and vary that force, as needed, to hold the pill in place.

What is meant by drug delivery?

Drug delivery is the method or process of administering a pharmaceutical compound to achieve a therapeutic effect in humans or animals. For the treatment of human diseases, nasal and pulmonary routes of drug delivery are gaining increasing importance.

How can we use magnetic nanoparticles for medical applications?

Magnetic nanoparticles find extensive use in medical applications.

They have been investigated for use in the following applications:
  1. Magnetic resonance imaging.
  2. Biomedicine.
  3. Magnetic particle imaging.
  4. Data storage.
  5. Nanofluids.
  6. Environmental remediation.
  7. Optical filters.

What is the application of nanoparticles?

Nanoparticles are used increasingly in catalysis to boost chemical reactions. This reduces the quantity of catalytic materials necessary to produce desired results, saving money and reducing pollutants. Two big applications are in petroleum refining and in automotive catalytic converters.

How are magnetic nanoparticles prepared?

In most studies of magnetic nanoparticles, scientists have tried to develop novel synthesis methods [2]. Liquid phase synthesis is one of the most common methods to produce inorganic nanoparticles. Many oxide nanoparticles, including ferrite particles, can be synthesized by co-precipitation.

How can nanotechnology help drug delivery?

Applying nanotechnology to drug delivery should achieve the following benefits:
  1. Improve the ability to deliver drugs that are poorly water soluble.
  2. Provide site-specific targeting to reduce drug accumulation within healthy tissue.
  3. Help retain the drug in the body long enough for effective treatment.

What is the main advantage of using nanotechnology for drug delivery?

The important technological advantages of nanoparticles used as drug carriers are high stability, high carrier capacity, feasibility of incorporation of both hydrophilic and hydrophobic substances, and feasibility of variable routes of administration, including oral application and inhalation.

How are nanoparticles used for drug targeting?

Nanoparticles can cross the blood-brain barrier following the opening of endothelium tight junctions by hyper-osmotic mannitol, which may provide sustained delivery of therapeutic agents for difficult-to-treat diseases like brain tumors (Kroll et al., 1998).

How are gold nanoparticles used in drug delivery?

Targeted drug delivery using nanoparticles allows directing the particles to specific tissues, improving bioavailability and solubility, minimizing toxicity, improving drug effect in the tissue, and protecting therapeutic agents from degradation [8], [9], [10].

What are the types of drug delivery systems?

Figure 1: Different routes of drug delivery.
  • Buccal drug delivery. …
  • Nasal drug delivery. …
  • Ocular drug delivery. …
  • Oral drug delivery. …
  • Pulmonary drug delivery. …
  • Sublingual drug delivery. …
  • Transdermal drug delivery. …
  • Vaginal/anal drug delivery.
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