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Leprosy Diagnosis and Classification

Leprosy Diagnosis and Classification

Leprosy has traditionally been classified into two major types, tuberculoid and lepromatous. Patients with tuberculoid leprosy have limited disease and relatively few bacteria in the skin and nerves, while lepromatous patients have widespread disease and large numbers of bacteria.

How leprosy is diagnosed?

To confirm the diagnosis, your doctor will take a sample of your skin or nerve (through a skin or nerve biopsy) to look for the bacteria under the microscope and may also do tests to rule out other skin diseases.

What are the 3 types of leprosy?

The first system recognizes three types of Hansen’s disease: tuberculoid, lepromatous, and borderline. A person’s immune response to the disease determines which of these types of Hansen’s disease they have: In tuberculoid Hansen’s disease, the immune response is good.

What is Ridley Jopling classification?

In the 1960s, Ridley and Jopling [1] proposed a histological classification scheme for leprosy that ranged in severity, beginning with early indeterminant (I) leprosy and continuing with polar tuberculoid (TT) leprosy, borderline tuberculoid (BT) leprosy, mid-borderline (BB) leprosy, borderline lepromatous (BL) leprosy …

What are the classification of leprosy?

Leprosy has traditionally been classified into two major types, tuberculoid and lepromatous. Patients with tuberculoid leprosy have limited disease and relatively few bacteria in the skin and nerves, while lepromatous patients have widespread disease and large numbers of bacteria.

What is the blood test for leprosy?

Phenolic glycolipid-1: This is a specific serologic test based on the detection of antibodies to phenolic glycolipid-1. This test yields a sensitivity of 95% for the detection of lepromatous leprosy but only 30% for tuberculoid leprosy.

What is ENL in leprosy?

Erythema nodosum leprosum (ENL), is an immune-mediated condition of leprosy.It is a multi-system disorder which can occurbefore, during or after completion of multidrug therapy for leprosy. ENL is often characterised by chronicity and recurrence.

Whats is a leper?

Leprosy is an infectious disease that causes severe, disfiguring skin sores and nerve damage in the arms, legs, and skin areas around your body. Leprosy has been around since ancient times. Outbreaks have affected people on every continent. But leprosy, also known as Hanson’s disease, isn’t that contagious.

What is MDT in leprosy?

Leprosy. Leprosy is curable with a combination of drugs known as multidrug therapy (MDT), as the treatment of leprosy with only one antileprosy drug (monotherapy) will result in development of drug resistance to that drug. The combination of drugs used in the MDT depends on the classification of the disease.

What is MB and PB leprosy?

Paucibacillary (PB): includes all smear-negative cases. Multibacillary (MB): includes all smear-positive cases. Classification (clinical): Paucibacillary single lesion leprosy: 1 skin lesion. Paucibacillary leprosy: 2 to 5 patches or lesions on the skin.

WHO leprosy guidelines?

In 1981, WHO recommended MDT. The currently recommended MDT regimen consists of medicines: dapsone, rifampicin and clofazimine. This treatment lasts six months for pauci-bacillary and 12 months for multi-bacillary cases. MDT kills the pathogen and cures the patient.

When is lepromin test positive?

A positive skin reaction may be seen in people with specific forms of leprosy, such as tuberculoid and borderline tuberculoid leprosy. People with lepromatous leprosy will not have a positive skin reaction.

What is Type 2 reaction in leprosy?

Erythema nodosum leprosum (ENL), also known as lepra type 2 reaction, is a complication of lepromatous leprosy. It is characterized by the development of inflamed subcutaneous nodules accompanied at times by fever, lymphadenopathy, and arthralgias.

What is leprae reaction?

Lepra reactions are inflammatory reactions occurring in leprosy, due to circulating immune complexes, vasculitis, or T-cell reaction which may be induced by treatment.

What is leprosy look like?

Signs of leprosy are painless ulcers, skin lesions of hypopigmented macules (flat, pale areas of skin), and eye damage (dryness, reduced blinking). Later, large ulcerations, loss of digits, skin nodules, and facial disfigurement may develop. The infection spreads from person to person by nasal secretions or droplets.

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