Cetuximab KRAS Testing
The Food and Drug Administration has approved a new cetuximab indication in colorectal cancer along with a genetic test to rule out patients who carry a KRAS mutation and therefore would not benefit from treatment.Jul 9, 2012
How is KRAS mutation detected?
What does KRAS positive mean?
How do you treat KRAS mutation?
What does KRAS mean in medical terms?
Is KRAS mutation treatable?
What does BRAF stand for?
What is KRAS G12C mutation?
Is KRAS a tumor suppressor gene?
Alterations in oncogenes, tumor-suppressor genes, and micro-RNA genes are important in pathogenesis of cancer (2). These alterations are a sequential multistep process that in the end results in neoplastic transformation.
Is KRAS the same as Ras?
Is KRAS a biomarker?
Why is KRAS Undruggable?
Are BRAF and KRAS mutually exclusive?
How common are KRAS mutations?
What happens when mutated KRAS?
Is KRAS mutation genetic?
What type of protein is KRAS?
What is KRAS negative?
Why is KRAS Hard Target?
What are KRAS mutated cancers?
How do KRAS inhibitors work?
NSCLCs with this mutation are often resistant to other targeted drugs such as EGFR inhibitors (see below). Sotorasib (Lumakras) is a type of drug known as a KRAS inhibitor. It works by attaching to the KRAS G12C protein, which keeps the cancer cell from growing.
What cancers have BRAF mutations?
Is it better to be BRAF positive or negative?
What are BRAF driven cancers?
How common is KRAS G12C?
Is sotorasib and immunotherapy?
What is KRAS inhibitor?
What is Lynch syndrome?
When was KRAS mutation discovered?
How many amino acids are in KRAS?
|Description:||Crystal Structure of small molecule ARS-1620 covalently bound to K-Ras G12C.|
What is the difference between KRAS and HRAS?
The Kras 4A isoform shares with Hras and Nras a post-translational modification that includes covalent attachment of a palmitoyl moiety, whereas the modification of the predominant Kras 4B is limited to farnesylation or geranylgeranylation6.